Browsing by Author "Orek, Cahit"
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Investigation of acetylcholinesterase and mammalian DNA topoisomerases, carbonic anhydrase inhibition profiles, and cytotoxic activity of novel bis(-aminoalkyl)phosphinic acid derivatives against human breast cancer
Dastan, Taner; Kocyigit, Umit M.; Dastan, Sevgi Durna; Kilickaya, Pakize Canturk; Taslimi, Parham; Cevik, Ozge; Koparir, Metin; Orek, Cahit; Gulcin, Ilhami; Cetin, Ahmet (WILEY, 2017)The aim of this study was to evaluate biologically active novel molecules having potentials to be drugs by their antitumor properties and by activities of apoptotic caspase and topoisomerase. Following syntheses of novel ... -
Investigation of anti-proliferative and antioxidative effects of some bis (alpha-amino) phosphinic acid derivatives
Dastan, Taner; Dastan, Sevgi Durna; Atas, Mehmet; Orek, Cahit; Koparir, Pelin; Parlak, Akif Evren; Baral, Inanc; Koparir, Metin; Cetin, Ahmet (UNIV KARACHI, 2016)Aminophosphinic acids which are organophosphorus compounds widely investigated for potential production of antibacterial, antitumor and antiviral materials. In vitro antioxidant, cytotoxic and antimicrobial activities of ... -
Synthesis and biological activities of some novel aminomethyl derivatives of 4-substituted-5-(2-thienyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones
Koparir, Metin; Orek, Cahit; Parlak, Akif Evren; Soylemez, Abdurrazak; Koparir, Pelin; Karatepe, Mustafa; Dastan, Sevgi Durna (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2013)A novel series of compounds were synthesized by cyclic condensation reaction of substituted isothiocyanate (2a-c) with 2-thiophenecarboxylic acid hydrazide (1) in the presence of ethyl alcohol, to obtain intermediate ... -
Synthesis and in vitro antioxidant evaluation of new bis(-aminoalkyl)phosphinic acid derivatives
Sarac, Kamiran; Orek, Cahit; Cetin, Ahmet; Dastan, Taner; Koparir, Pelin; Dastan, Sevgi Durna; Koparir, Metin (TAYLOR & FRANCIS LTD, 2016)Diamines were added to arylaldehydes in ethanol, which resulted in corresponding diimines. Novel bis-1-aminophosphinic acid compounds were synthesized through the interaction of diimines and hypophosphorous acid. The new ...